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Proceedings Paper

Noninvasive assessment of tissue distribution and tumor pharmacokinetics of Pc 181, a silicon phthalocyanine analogue, in mice
Author(s): Lihua Bai; Jianxia Guo; Dana M. Clausen; Julie L. Eiseman
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Paper Abstract

Objective: In in vitro photodynamic therapy, the LD50 of Pc 181 has been reported to be 7 to 8 times less than that of silicon phthalocyanine 4 (Pc 4). The Optical Pharmacokinetic System (OPS) can measure photosensitizer concentrations in accessible tissues non-invasively. We used OPS to evaluate the tumor pharmacokinetics of Pc 181 and Pc 4 and the tissue drug distribution in SCID mice bearing either human breast cancer MDA-MB-231 or human head and neck squamous cell carcinoma SCC-15 xenografts. Methods: Following iv administration of 2.5 mg/kg Pc 181 or 2 mg/kg Pc 4 to SCID mice, OPS measurements were taken on tumor and normal tissues between 5 and 4320 min in vivo or in situ. Results: Large variations in tumor Pc 181 concentrations were observed among mice. In MDA-MB-231 tumors, the Pc 181 concentration peaked at 240 min, and was retained in the tumor. Tumor Pc 181 concentrations were much less than the tumor Pc 4 concentrations at an equimolar dose. Pc 181 concentrations were the highest in liver, followed by spleen, and kidney. In mice bearing SCC-15 xenografts, skin and underlying tissue Pc 181 concentrations were higher than tumor concentrations at all time points examined. Conclusions: This first Pc 181 pharmacokinetics study described a tissue Pc 181 distribution similar to that of Pc 4. However, tumor Pc 181 concentrations were lower than those of Pc 4 at equimolar doses.

Paper Details

Date Published: 2 March 2010
PDF: 6 pages
Proc. SPIE 7551, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIX, 75510T (2 March 2010); doi: 10.1117/12.842357
Show Author Affiliations
Lihua Bai, Univ. of Pittsburgh School of Medicine (United States)
Univ. of Pittsburgh Cancer Institute (United States)
Jianxia Guo, Univ. of Pittsburgh School of Medicine (United States)
Univ. of Pittsburgh Cancer Institute (United States)
Dana M. Clausen, Univ. of Pittsburgh School of Medicine (United States)
Univ. of Pittsburgh Cancer Institute (United States)
Julie L. Eiseman, Univ. of Pittsburgh School of Medicine (United States)
Univ. of Pittsburgh Cancer Institute (United States)


Published in SPIE Proceedings Vol. 7551:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIX
David H. Kessel, Editor(s)

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