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Proceedings Paper

Monitoring small changes in blood hematocrit using phase sensitive spectral domain optical coherence tomography
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Paper Abstract

A new method for monitoring ultra-small changes in blood hematocrit (~0.2%) based on measurement of refractive index changes in vitro using Phase Sensitive Spectral Domain Optical Coherence Tomography modality (PhS-SDOCT) is introduced. The developed system has an axial resolution of ~8 μm, phase sensitivity of ±0.01 radians, imaging depth of 3.4 ± 0.01 mm in air, and image acquisition speed of 29 kHz. The experimental accuracy for monitoring refractive index changes as a function of hematocrit level in blood is found to be ±1.5x10-4 (±0.2%). Obtained results indicate that the PhS-SDOCT can be used to monitor ultra-small changes in the hematocrit and in vitro and, potentially, in tissue blood vessels in vivo.

Paper Details

Date Published: 19 February 2010
PDF: 4 pages
Proc. SPIE 7554, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIV, 755424 (19 February 2010); doi: 10.1117/12.842289
Show Author Affiliations
Venu Gopal Reddy Manne, Univ. of Houston (United States)
Ravi Kiran Manapuram, Univ. of Houston (United States)
Narendran Sudheendran, Univ. of Houston (United States)
Kirill V. Larin, Univ. of Houston (United States)
Saratov State Univ. (Russian Federation)

Published in SPIE Proceedings Vol. 7554:
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIV
Joseph A. Izatt; James G. Fujimoto; Valery V. Tuchin, Editor(s)

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