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Proceedings Paper

Study on dynamics of photon migration in human breast based on three-dimensional Monte Carlo modeling
Author(s): Ching-Cheng Chuang; Chung-Ming Chen; Chia-Yen Lee; Jui-che Tsai; Chih-Wei Lu; Chia-Wei Sun
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Paper Abstract

The scattering and absorption properties of human breast are very important for cancer diagnosis based on diffuse optical tomography (DOT). In this study, the dynamics of photon migration in three-dimensional human breast model with various source-detector separations is simulated based on a Monte Carlo algorithm. The three-dimensional human breast structure is obtained from in vivo MRI image. The breast model consists of skin, fatty tissue, glandular tissue, sternum and ribcage. The backscattered diffuse photons from each layer in breast are recorded by marking the deepest layer which every photon can reach. The experimental results indicate that the re-emitted photons contain more information from deep tissue regions with the source-detector separations because of the strong dependence to the resolution and sensitivity in DOT imaging. The geometric position of the source-detector separations were optimized in this study. The different sizes of breast tumor were modeled to analysis of optical image characterizations. Finally, the tumor images from different deep information were obtained with temporal profiles.

Paper Details

Date Published: 26 February 2010
PDF: 8 pages
Proc. SPIE 7573, Biomedical Applications of Light Scattering IV, 757319 (26 February 2010); doi: 10.1117/12.842230
Show Author Affiliations
Ching-Cheng Chuang, National Taiwan Univ. (Taiwan)
Chung-Ming Chen, National Taiwan Univ. (Taiwan)
Chia-Yen Lee, National Taiwan Univ. (Taiwan)
Jui-che Tsai, National Taiwan Univ. (Taiwan)
Chih-Wei Lu, Industrial Technology Research Institute (Taiwan)
Chia-Wei Sun, National Yang-Ming Univ. (Taiwan)
National Chiao Tung Univ. (Taiwan)

Published in SPIE Proceedings Vol. 7573:
Biomedical Applications of Light Scattering IV
Adam P. Wax; Vadim Backman, Editor(s)

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