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Proceedings Paper

Photoacoustic imaging of vascular networks in transgenic mice
Author(s): J. G. Laufer; J. O. Cleary; E. Z. Zhang; M. F. Lythgoe; P. C. Beard
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Paper Abstract

The preferential absorption of near infrared light by blood makes photoacoustic imaging well suited to visualising vascular structures in soft tissue. In addition, the spectroscopic specificity of tissue chromophores can be exploited by acquiring images at multiple excitation wavelengths. This allows the quantification of endogenous chromophores, such as oxy- and deoxyhaemoglobin, and hence blood oxygenation, and the detection of exogenous chromophores, such as functionalised contrast agents. More importantly, this approach has the potential to visualise the spatial distribution of low concentrations of functionalised contrast agents against the strong background absorption of the endogenous chromophores. This has a large number of applications in the life sciences. One example is the structural and functional phenotyping of transgenic mice for the study of the genetic origins of vascular malformations, such as heart defects. In this study, photoacoustic images of mouse embryos have been acquired to study the development of the vasculature following specific genetic knockouts.

Paper Details

Date Published: 23 February 2010
PDF: 5 pages
Proc. SPIE 7564, Photons Plus Ultrasound: Imaging and Sensing 2010, 75641A (23 February 2010); doi: 10.1117/12.842204
Show Author Affiliations
J. G. Laufer, Univ. College London (United Kingdom)
J. O. Cleary, Univ. College London (United Kingdom)
E. Z. Zhang, Univ. College London (United Kingdom)
M. F. Lythgoe, Univ. College London (United Kingdom)
P. C. Beard, Univ. College London (United Kingdom)

Published in SPIE Proceedings Vol. 7564:
Photons Plus Ultrasound: Imaging and Sensing 2010
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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