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Proceedings Paper

Photon propagation correction in 3D photoacoustic image reconstruction using Monte Carlo simulation
Author(s): Yaw Jye Cheong; Keith M. Stantz
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Paper Abstract

Purpose: The purpose of this study is to develop a new 3-D iterative Monte Carlo algorithm to recover the heterogeneous distribution of molecular absorbers with a solid tumor. Introduction: Spectroscopic imaging (PCT-S) has the potential to identify a molecular species and quantify its concentration with high spatial fidelity. To accomplish this task, tissue attenuation losses during photon propagation in heterogeneous 3D objects is necessary. An iterative recovery algorithm has been developed to extract 3D heterogeneous parametric maps of absorption coefficients implementing a MC algorithm based on a single source photoacoustic scanner and to determine the influence of the reduced scattering coefficient on the uncertainty of recovered absorption coefficient. Material and Methods: This algorithm is tested for spheres and ellipsoids embedded in simulated mouse torso with optical absorption values ranging from 0.01-0.5/cm, for the same objects where the optical scattering is unknown (μs'=7-13/cm), and for a heterogeneous distribution of absorbers. Results: Systemic and statistical errors in ma with a priori knowledge of μs' and g are <2% (sphere) and <4% (ellipsoid) for all ma and without a priori knowledge of ms' is <3% and <6%. For heterogenenous distributions of ma, errors are <4% and <5.5% for each object with a prior knowledge of ms' and g, and to 7 and 14% when μs' varied from 7-13/cm. Conclusions: A Monte Carlo code has been successfully developed and used to correct for photon propagation effects in simulated objects consistent with tumors.

Paper Details

Date Published: 23 February 2010
PDF: 10 pages
Proc. SPIE 7564, Photons Plus Ultrasound: Imaging and Sensing 2010, 75640G (23 February 2010); doi: 10.1117/12.842196
Show Author Affiliations
Yaw Jye Cheong, IUPUI (United States)
BrainLAB, Inc. (United States)
Keith M. Stantz, Purdue Univ. (United States)
Indiana Univ. (United States)

Published in SPIE Proceedings Vol. 7564:
Photons Plus Ultrasound: Imaging and Sensing 2010
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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