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Proceedings Paper

Challenge for spectroscopic tomography of biomembrane using imaging type two-dimensional Fourier spectroscopy
Author(s): Wei Qi; Ichiro Ishimaru
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Paper Abstract

We propose an image-producing Fourier spectroscopic technology that enables two-dimensional spectroscopic images to be obtained within the focusing plane alone. This technology incorporates auto-correlational phase-shift interferometry that uses only object light generated by the bright points that optically make up the object. We are currently involved in studies of non-invasive technologies used to measure blood components such as glucose and lipids, which are measured for use in daily living. Previous studies have investigated non-invasive technologies that measure blood glucose levels by utilizing near-infrared light that permeates the skin well. It has been confirmed that subtle changes in the concentration of a glucose solution, a sample used to measure the glucose level, can be measured by analyzing the spectroscopic characteristics of near-infrared light; however, when applied to a biomembrane, technology such as this is incapable of precisely measuring the glucose level because light diffusion within the skin disturbs the measurement. Our proposed technology enables two-dimensional spectroscopy to a limited depth below the skin covered by the measurement. Specifically, our technology concentrates only on the vascular territory near the skin surface, which is only minimally affected by light diffusion, as discussed previously; the spectroscopic characteristics of this territory are obtained and the glucose level can be measured with good sensitivity. In this paper we propose an image-producing Fourier spectroscopy method that is used as the measuring technology in producing a three-dimensional spectroscopic image.

Paper Details

Date Published: 26 February 2010
PDF: 8 pages
Proc. SPIE 7572, Optical Diagnostics and Sensing X: Toward Point-of-Care Diagnostics, 757207 (26 February 2010); doi: 10.1117/12.841520
Show Author Affiliations
Wei Qi, Kagawa Univ. (Japan)
Ichiro Ishimaru, Kagawa Univ. (Japan)

Published in SPIE Proceedings Vol. 7572:
Optical Diagnostics and Sensing X: Toward Point-of-Care Diagnostics
Gerard L. Coté, Editor(s)

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