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Proceedings Paper

Dynamic differential imaging of intrinsic optical responses in the retina
Author(s): Xin-Cheng Yao; Yang-Guo Li; Lei Liu; Frank Amthor
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Paper Abstract

High resolution monitoring of stimulus-evoked retinal neural activities is important for understanding retinal neural mechanisms, and for diagnosis of retinal disease and evaluation of treatment. Fast intrinsic optical signals (IOSs), which have the time courses comparable to retinal electrophysiological responses, hold the promise for high resolution imaging of retinal neural activities. However, application of fast IOS imaging has been hindered by contamination of slow, high magnitude, optical responses associated with transient hemodynamic and metabolic changes. We recently demonstrated the feasibility of separating fast IOSs from slow optical responses by combined dynamic differential imaging and high frequency flicker stimulation.

Paper Details

Date Published: 4 March 2010
PDF: 5 pages
Proc. SPIE 7548, Photonic Therapeutics and Diagnostics VI, 754845 (4 March 2010); doi: 10.1117/12.841417
Show Author Affiliations
Xin-Cheng Yao, The Univ. of Alabama at Birmingham (United States)
Yang-Guo Li, The Univ. of Alabama at Birmingham (United States)
Lei Liu, The Univ. of Alabama at Birmingham (United States)
Frank Amthor, The Univ. of Alabama at Birmingham (United States)

Published in SPIE Proceedings Vol. 7548:
Photonic Therapeutics and Diagnostics VI
Anita Mahadevan-Jansen; Andreas Mandelis; Brian Jet-Fei Wong M.D.; Nikiforos Kollias; Henry Hirschberg M.D.; Kenton W. Gregory M.D.; Reza S. Malek; E. Duco Jansen; Guillermo J. Tearney; Steen J. Madsen; Bernard Choi; Justus F. R. Ilgner; Haishan Zeng; Laura Marcu, Editor(s)

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