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Proceedings Paper

Integrated intravascular optical coherence tomography (OCT) - ultrasound (US) imaging system
Author(s): Jiechen Yin; Hao-Chung Yang; Xiang Li; Qifa Zhou; Changhong Hu; Jun Zhang; K. Kirk Shung; Zhongping Chen
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Paper Abstract

Optical coherence tomography (OCT) and intravascular ultrasound (IVUS) are considered two complementary imaging techniques in the detection and diagnosis of atherosclerosis. OCT permits visualization of micron-scale features of atherosclerosis plaque, and IVUS offers full imaging depth of vessel wall. Under the guidance of IVUS, minimal amount of flushing agent will be needed to obtain OCT imaging of the interested area. We report on a dual-modality optical coherence tomography (OCT) - ultrasound (US) system for intravascular imaging. To the best of our knowledge, we have developed the first integrated OCT-US probe that combines OCT optical components with an ultrasound transducer. The OCT optical components mainly consist of a single mode fiber, a gradient index (GRIN) lens for light beam focusing, and a right-angled prism for reflecting light into biological tissue. A 40MHz PZT-5H side-viewing ultrasound transducer was fabricated to obtain the ultrasound image. These components were integrated into a single probe, enabling both OCT and ultrasound imaging at the same time. In vitro OCT and ultrasound images of a rabbit aorta were obtained using this dual-modality imaging system. This study demonstrates the feasibility of an OCT-US system for intravascular imaging which is expected to have a prominent impact on early detection and characterization of atherosclerosis.

Paper Details

Date Published: 23 February 2010
PDF: 5 pages
Proc. SPIE 7557, Multimodal Biomedical Imaging V, 75570D (23 February 2010); doi: 10.1117/12.841375
Show Author Affiliations
Jiechen Yin, Univ. of California, Irvine (United States)
Hao-Chung Yang, The Univ. of Southern California (United States)
Xiang Li, The Univ. of Southern California (United States)
Qifa Zhou, The Univ. of Southern California (United States)
Changhong Hu, The Univ. of Southern California (United States)
Jun Zhang, Beckman Laser Institute (United States)
K. Kirk Shung, The Univ. of Southern California (United States)
Zhongping Chen, Univ. of California, Irvine (United States)
Beckman Laser Institute (United States)

Published in SPIE Proceedings Vol. 7557:
Multimodal Biomedical Imaging V
Fred S. Azar; Xavier Intes, Editor(s)

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