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Proceedings Paper

Photonic approach to the selective inactivation of viruses with a near-infrared ultrashort pulsed laser
Author(s): K. T. Tsen; Shaw-Wei D. Tsen; Q. Fu; S. M. Lindsay; K. Kibler; B. Jacobs; T. C. Wu; Zhe Li; Hao Yan; Stephanie Cope; Sara Vaiana; Juliann G. Kiang
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Paper Abstract

We report a photonic approach for selective inactivation of viruses with a near-infrared ultrashort pulsed (USP) laser. We demonstrate that this method can selectively inactivate viral particles ranging from nonpathogenic viruses such as M13 bacteriophage, tobacco mosaic virus (TMV) to pathogenic viruses like human papillomavirus (HPV) and human immunodeficiency virus (HIV). At the same time sensitive materials like human Jurkat T cells, human red blood cells, and mouse dendritic cells remain unharmed. Our photonic approach could be used for the disinfection of viral pathogens in blood products and for the treatment of blood-borne viral diseases in the clinic.

Paper Details

Date Published: 11 February 2010
PDF: 10 pages
Proc. SPIE 7561, Optical Biopsy VII, 75610W (11 February 2010); doi: 10.1117/12.841316
Show Author Affiliations
K. T. Tsen, Arizona State Univ. (United States)
Shaw-Wei D. Tsen, Washington Univ. School of Medicine (United States)
Q. Fu, Arizona State Univ. (United States)
S. M. Lindsay, Arizona State Univ. (United States)
K. Kibler, Arizona State Univ. (United States)
B. Jacobs, Arizona State Univ. (United States)
T. C. Wu, The Johns Hopkins Medical Institutions (United States)
Zhe Li, Arizona State Univ. (United States)
Hao Yan, Arizona State Univ. (United States)
Stephanie Cope, Arizona State Univ. (United States)
Sara Vaiana, Arizona State Univ. (United States)
Juliann G. Kiang, Uniformed Services Univ. of the Health Sciences (United States)

Published in SPIE Proceedings Vol. 7561:
Optical Biopsy VII
Robert R. Alfano, Editor(s)

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