
Proceedings Paper
Biofilms of chitosan-gold nanorods as a novel composite for the laser welding of biological tissueFormat | Member Price | Non-Member Price |
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Paper Abstract
Gold nanorods (GNRs) exhibit intense localized plasmon resonances at optical frequencies in the near infrared (NIR),
which is the window where the penetration of light into the body is maximal. Upon excitation with a NIR laser, a strong
photothermal effect is produced, which can be exploited to develop minimally invasive therapies. Here we prove the use
of chitosan-GNRs films as a novel NIR sensitive nanocomposite for the photothermal conversion of NIR laser light
during surgical interventions of tissue welding. Chitosan is an attractive biomaterial due to its biodegradability,
biocompatibility, hemostatic, antimicrobial and wound healing-promoting activity. Colloidal GNRs were embedded in
chitosan based, highly stabilized, flexible and easy-to-handle films, which were stored in water until the time of surgery.
The chitosan-GNRs films were first positioned on freshly explanted rabbit tendon samples. Then, by administration of
single pulses ranging from 80 to 140 ms duration and 0.5 to 1.5 W power delivered by a 300-μm optic fiber coupled
with a 810 nm diode laser, spots of local thermally-induced adhesion characterized by a tensile strength of ~ 10 kPa
were obtained. The present results are encouraging toward the development of a novel minimally-invasive technology
based on the application of bioderived nanoplasmonic materials to biomedical optics.
Paper Details
Date Published: 12 February 2010
PDF: 4 pages
Proc. SPIE 7574, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications VII, 75740U (12 February 2010); doi: 10.1117/12.840923
Published in SPIE Proceedings Vol. 7574:
Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications VII
Alexander N. Cartwright; Dan V. Nicolau, Editor(s)
PDF: 4 pages
Proc. SPIE 7574, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications VII, 75740U (12 February 2010); doi: 10.1117/12.840923
Show Author Affiliations
P. Matteini, Institute of Applied Physics, National Research Council (Italy)
F. Ratto, Institute of Applied Physics, National Research Council (Italy)
F. Ratto, Institute of Applied Physics, National Research Council (Italy)
Published in SPIE Proceedings Vol. 7574:
Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications VII
Alexander N. Cartwright; Dan V. Nicolau, Editor(s)
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