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Proceedings Paper

Plasmon resonance gold nanoparticles for improving optical diagnostics and photothermal therapy of tumor
Author(s): E. V. Zagainova; M. A. Sirotkina; M. V. Shirmanova; V. V. Elagin; M. Kirillin; P. Agrba; V. A. Kamensky; V. A. Nadtochenko
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Paper Abstract

The study was performed on 16 CBA-line female mice with transplanted cervical cancer. 0.2 ml of gold nanoparticle solution with a concentration of 109 particles/ml were injected into the animals intravenously. The particles were 200-250 nm in size; the plasmon-resonance related extinction maximum was at the wavelength of 850-950 nm. Accumulation of the nanoparticles into tumor node was visualized by the method of optical coherence tomography (OCT). When the accumulation of nanoparticles in the tumor was maximal, hyperthermia was accomplished using the LSP-AZOR laser setup generating cw radiation at 810 nm. The duration of exposition was 20 min. The therapeutical effect was assessed by the rate of tumor growth inhibition (TGI, %). Determining the instant when nanoparticle concentration in tumor tissue reaches its maximum enables more efficient laser impact. The use of nanoparticles decreases laser irradiation power and ensures local action.

Paper Details

Date Published: 16 February 2010
PDF: 6 pages
Proc. SPIE 7577, Plasmonics in Biology and Medicine VII, 75770P (16 February 2010); doi: 10.1117/12.840638
Show Author Affiliations
E. V. Zagainova, Nizhny Novgorod State Medical Academy (Russian Federation)
M. A. Sirotkina, Nizhny Novgorod State Medical Academy (Russian Federation)
M. V. Shirmanova, Nizhny Novgorod State Medical Academy (Russian Federation)
V. V. Elagin, Nizhny Novgorod State Medical Academy (Russian Federation)
M. Kirillin, Institute of Applied Physics (Russian Federation)
P. Agrba, Institute of Applied Physics (Russian Federation)
V. A. Kamensky, Institute of Applied Physics (Russian Federation)
V. A. Nadtochenko, N.N. Semenov Institute of Chemical Physics (Russian Federation)


Published in SPIE Proceedings Vol. 7577:
Plasmonics in Biology and Medicine VII
Tuan Vo-Dinh; Joseph R. Lakowicz, Editor(s)

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