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Proceedings Paper

Involvement of ASK1 activation in apoptosis induced by NPe6-PDT
Author(s): Lei Liu; Zhen-zhen Zhang; Zhigang Zhang
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Paper Abstract

Photodynamic therapy (PDT) employing photosensiter N-aspartyl chlorin e6 (NPe6) can induce lysosome disruption and initiate apoptotic pathway. Apoptosis signal-regulating kinase (ASK1) is an important regulator of apoptosis in response to various stresses, such as reactive oxygen species (ROS), endoplasmic reticulum (ER) stress, lipopolysaccharide (LPS) and calcium influx. In this study, we investigated the molecular mechanisms of apoptosis induced by NPe6-PDT in ASTC-a-1 cells. The results showed that the activities of ASK1 increased in response to NPe6-PDT. Over-expression of wild-type or activated mutant of ASK1 could obviously decrease cell viability and increase cell death; while inhibition of ASK1 significantly decreased cell apoptosis. These results suggested that ASK1 plays an important role in apoptosis induced by NPe6-PDT.

Paper Details

Date Published: 11 February 2010
PDF: 7 pages
Proc. SPIE 7565, Biophotonics and Immune Responses V, 75650L (11 February 2010); doi: 10.1117/12.840472
Show Author Affiliations
Lei Liu, South China Normal Univ. (China)
Zhen-zhen Zhang, South China Normal Univ. (China)
Zhigang Zhang, South China Normal Univ. (China)

Published in SPIE Proceedings Vol. 7565:
Biophotonics and Immune Responses V
Wei R. Chen, Editor(s)

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