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Proceedings Paper

Near-IR optical properties of canine prostate tissue using oblique-incidence reflectometry
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Paper Abstract

Optical imaging systems utilizing near-infrared light sources such as optical coherence tomography (OCT) have recently been used for imaging the prostate gland. However, the optimal wavelength for deep imaging of the prostate has yet to be determined. The objective of this study is to determine the optimal near-infrared wavelength for OCT imaging of the prostate using a system that has the potential to be used in an in vivo model. An obliqueincidence single point measurement technique using a normal-detector scanning system was implemented to determine the absorption (μa) and reduced scattering coefficients (μ's) of fresh canine prostate tissue, ex vivo, from the diffuse reflectance profile of near-IR light as a function of source-detector distance. The effective attenuation coefficient (μeff) and optical penetration depth (OPD) were then calculated for near-IR wavelengths of 1064, 1307, and 1555 nm. A total of ten canine samples were used for this study. At wavelengths of 1064, 1307, and 1555 nm, the mean absorption coefficients measured 0.08 ± 0.03, 0.12 ± 0.04, and 0.23 ± 0.09 cm-1, respectively. The mean reduced scattering coefficients measured 16.60 ± 0.95, 14.30 ± 1.14, and 10.98 ± 2.35 cm-1. The effective attenuation coefficients were calculated to be 2.00, 2.28, and 2.78 cm-1, yielding OPD's of 0.5, 0.44, and 0.36 cm at 1064, 1307, and 1555 nm. OCT imaging studies of the prostate may benefit from replacement of commonly used 1310 nm broadband light sources with 1064 nm sources.

Paper Details

Date Published: 2 March 2010
PDF: 6 pages
Proc. SPIE 7548, Photonic Therapeutics and Diagnostics VI, 75480Z (2 March 2010); doi: 10.1117/12.839598
Show Author Affiliations
Shahab Chitchian, The Univ. of North Carolina at Charlotte (United States)
Nathaniel M. Fried, The Univ. of North Carolina at Charlotte (United States)
Johns Hopkins Medical Institutions (United States)

Published in SPIE Proceedings Vol. 7548:
Photonic Therapeutics and Diagnostics VI
Anita Mahadevan-Jansen; Andreas Mandelis; Brian Jet-Fei Wong M.D.; Nikiforos Kollias; Henry Hirschberg M.D.; Kenton W. Gregory M.D.; Reza S. Malek; E. Duco Jansen; Guillermo J. Tearney; Steen J. Madsen; Bernard Choi; Justus F. R. Ilgner; Haishan Zeng; Laura Marcu, Editor(s)

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