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Proceedings Paper

A comparative investigation on linear inversion schemes in fluorescence lifetime tomography
Author(s): Feng Gao; Meng Jing; Yuting Jiao; Patrick Poulet; Limin Zhang; Huijuan Zhao
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Paper Abstract

Fluorescence lifetime tomography (FLT) is an emerging imaging modality that seeks for recovering distributions of the fluorescent yield and lifetime inside in vivo tissues. This technique, mainly based on time-domain instrumentation, has found promising applications in small-animal imaging for studying tumor pathology and for drug development. As one of the model-based imaging methods, FLT can be finalized with inverting an underdetermined, ill-posed linear system with regard to both the parameters, for which several methods has been adopted. This paper concisely revises the main facts of three commonly-used linear inversions: algebraic reconstruction technique, truncated singular value decomposition and conjugate gradient descent, and presents a comparative investigation on these methods in terms of the image quality and noise robustness.

Paper Details

Date Published: 23 February 2010
PDF: 12 pages
Proc. SPIE 7557, Multimodal Biomedical Imaging V, 75570N (23 February 2010); doi: 10.1117/12.834835
Show Author Affiliations
Feng Gao, Tianjin Univ. (China)
Lab. d'Imagerie et de Neurosciences Cognitives, CNRS, Univ. de Strasbourg (France)
Meng Jing, Tianjin Univ. (China)
Yuting Jiao, Tianjin Univ. (China)
Patrick Poulet, Lab. d'Imagerie et de Neurosciences Cognitives, CNRS, Univ. de Strasbourg (France)
Limin Zhang, Tianjin Univ. (China)
Huijuan Zhao, Tianjin Univ. (China)

Published in SPIE Proceedings Vol. 7557:
Multimodal Biomedical Imaging V
Fred S. Azar; Xavier Intes, Editor(s)

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