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Proceedings Paper

Methods for nanoparticle labeling of ricin and effect on toxicity
Author(s): Alastair W. Wark; Jun Yu; Christopher D. Lindsay; Paola Nativo; Duncan Graham
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Paper Abstract

The unique optical properties associated with nanostructured materials that support the excitation of surface plasmons offer many new opportunities for the enhanced optical investigation of biological materials that pose a security threat. In particular, ricin is considered a significant bioterrorism risk due to its high toxicity combined with its ready availability as a byproduct in castor oil production. Therefore, the development of optical techniques capable of rapid on-site toxin detection with high molecular specificity and sensitivity continues to be of significant importance. Furthermore, understanding of the ricin cell entry and intracellular pathways remains poor due to a lack of suitable bioanalytical techniques. Initial work aimed at simultaneously tackling both these issues is described where different approaches for the nanoparticle labeling of ricin are investigated along with changes in ricin toxicity associated with the labeling process.

Paper Details

Date Published: 17 September 2009
PDF: 7 pages
Proc. SPIE 7486, Optics and Photonics for Counterterrorism and Crime Fighting V, 748604 (17 September 2009); doi: 10.1117/12.833545
Show Author Affiliations
Alastair W. Wark, Univ. of Strathclyde (United Kingdom)
Jun Yu, Univ. of Strathclyde (United Kingdom)
Christopher D. Lindsay, Defence Science and Technology Lab. (United Kingdom)
Paola Nativo, Univ. of Strathclyde (United Kingdom)
Duncan Graham, Univ. of Strathclyde (United Kingdom)

Published in SPIE Proceedings Vol. 7486:
Optics and Photonics for Counterterrorism and Crime Fighting V
Colin Lewis, Editor(s)

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