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Proceedings Paper

Dual-modality molecular imaging for small animals using fluorescence and x-ray computed tomography
Author(s): Yuting Lin; William C. Barber; Jan S. Iwanczyk; Einar Nygard; Nail Malakov; Neal E. Hartsough; Thulasi Gandhi; Werner W. Roeck; Orhan Nalcioglu; Gultekin Gulsen
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Paper Abstract

We demonstrate the feasibility of using a dual-modality fluorescence and x-ray computed tomography (CT) system for quantitative molecular imaging with phantom studies. A CCD based non-contact FT system, which can take measurements from multiple views was built. High-resolution X-Ray CT was used to obtain structural information from the phantom. A 3.6 mm diameter fluorescence inclusion was deeply embedded in the heterogeneous optical background. The results demonstrated that the fluorophore concentration can only be obtained accurately when guided by the a priori information provided by the x-ray CT.

Paper Details

Date Published: 1 July 2009
PDF: 6 pages
Proc. SPIE 7370, Molecular Imaging II, 73700G (1 July 2009); doi: 10.1117/12.831719
Show Author Affiliations
Yuting Lin, Univ. of California, Irvine (United States)
William C. Barber, DxRay, Inc. (United States)
Jan S. Iwanczyk, DxRay, Inc. (United States)
Einar Nygard, DxRay, Inc. (United States)
Nail Malakov, DxRay, Inc. (United States)
Neal E. Hartsough, DxRay, Inc. (United States)
Thulasi Gandhi, DxRay, Inc. (United States)
Werner W. Roeck, Univ. of California, Irvine (United States)
Orhan Nalcioglu, Univ. of California, Irvine (United States)
Gultekin Gulsen, Univ. of California, Irvine (United States)

Published in SPIE Proceedings Vol. 7370:
Molecular Imaging II
Kai Licha; Charles P. Lin, Editor(s)

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