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Proceedings Paper

Simultaneously reconstructing fluorescent yield and lifetime from time-resolved transmittances of a small-animal-sized phantom
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Paper Abstract

A full three-dimensional, featured-data algorithm for time-domain diffuse fluorescence tomography is presented, which inverts the Laplace-transformed time-domain coupled diffusion equations and employs a pair of real-domain transform-factors to effectively separate the fluorescent yield and lifetime parameters. By use of a multi-channel time-correlation single photon counting system and a normalized Born formulation for the inversion, the proposed scheme is experimentally validated to achieve simultaneous reconstruction of the fluorescent yield and lifetime distributions with a reasonable accuracy.

Paper Details

Date Published: 9 July 2009
PDF: 8 pages
Proc. SPIE 7369, Diffuse Optical Imaging II, 73691H (9 July 2009); doi: 10.1117/12.831670
Show Author Affiliations
Feng Gao, Tianjin Univ. (China)
Lab. d'Imagerie et de Neurosciences Cognitives, Univ. de Strasbourg, CNRS (France)
Limin Zhang, Tianjin Univ. (China)
Patrick Poulet, Lab. d'Imagerie et de Neurosciences Cognitives, Univ. de Strasbourg, CNRS (France)
Jiao Li, Tianjin Univ. (China)
Huijuan Zhao, Tianjin Univ. (China)
Yukio Yamada, Univ. of Electro-Communications (Japan)

Published in SPIE Proceedings Vol. 7369:
Diffuse Optical Imaging II
Rinaldo Cubeddu; Andreas H. Hielscher, Editor(s)

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