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Proceedings Paper

Palliative photodynamic therapy for biliary tract carcinoma may improve survival and has a similar outcome to attempted curative surgery with positive resection margins
Author(s): Stephen P. Pereira; W. Rudiger Matull; Dipok K. Dhar; Laskshmana Ayaru; Neomal S. Sandanayake; Michael H. Chapman
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Paper Abstract

There is a need for better management strategies to improve survival and quality of life in patients with biliary tract cancer (BTC). We compared treatment outcomes in 321 patients (median age 65 years, range 29-102; F:M; 1:1) with a final diagnosis of BTC (cholangiocarcinoma n=237, gallbladder cancer n=84) seen in a tertiary referral cancer centre between 1998-2007. Of 89 (28%) patients who underwent surgical intervention with curative intent, 38% had R0 resections and had the most favourable outcome, with a 3 year survival of 57%. Even though PDT patients had more advanced clinical T-stages, their survival was similar to those treated with attempted curative surgery which resulted in R1/2 resections (median survival 12 vs. 13 months, ns). In a subgroup of 36 patients with locally advanced BTC treated with PDT as part of a prospective phase II study, the median survival was 12 (range 2-51) months, compared with 5 months in matched historical controls treated with stenting alone (p < 0.0001). In this large UK series, long-term survival with BTC was only achieved in surgical patients with R0 resection margins. Palliative PDT resulted in similar survival to those with curatively intended R1/R2 resections.

Paper Details

Date Published: 13 July 2009
PDF: 9 pages
Proc. SPIE 7380, Photodynamic Therapy: Back to the Future, 73800V (13 July 2009); doi: 10.1117/12.828450
Show Author Affiliations
Stephen P. Pereira, Univ. College London (United Kingdom)
W. Rudiger Matull, Univ. College London (United Kingdom)
Dipok K. Dhar, Univ. College London (United Kingdom)
Laskshmana Ayaru, Univ. College London (United Kingdom)
Neomal S. Sandanayake, Univ. College London (United Kingdom)
Michael H. Chapman, Univ. College London (United Kingdom)

Published in SPIE Proceedings Vol. 7380:
Photodynamic Therapy: Back to the Future
David H. Kessel, Editor(s)

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