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Proceedings Paper

A hybrid CMOS-microfluidic contact imaging microsystem
Author(s): Ritu Raj Singh; Lian Leng; Axel Guenther; Roman Genov
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Paper Abstract

A hybrid CMOS/Microfluidic microsystem is presented. The microsystem integrates a soft polymer microfluidic network with a 64x128 pixel imager fabricated in low-cost standard 0.35 micron CMOS technology. The multiple microfluidic channels facilitate in-situ photochemical reactions of analytes and their detection directly on the surface of the CMOS photosensor array. The promixity between the analyte and the photosensor enhances the microsystem sensitivity, thus requiring only microliter volumes of the sample. Circuit techniques such as pixel binning and a two transistor reset path technique are employed to improve the imager sensitivity. The integrated microsystem is validated in on-chip chemiluminescence detection of luminol for the two microfluidic network prototypes designed.

Paper Details

Date Published: 21 August 2009
PDF: 9 pages
Proc. SPIE 7397, Biosensing II, 739712 (21 August 2009); doi: 10.1117/12.827862
Show Author Affiliations
Ritu Raj Singh, Univ. of Toronto (Canada)
Lian Leng, Univ. of Toronto (Canada)
Axel Guenther, Univ. of Toronto (Canada)
Roman Genov, Univ. of Toronto (Canada)

Published in SPIE Proceedings Vol. 7397:
Biosensing II
Manijeh Razeghi; Hooman Mohseni, Editor(s)

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