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Proceedings Paper

Silicon-based mesoporous photonic crystals: towards single cell optical biosensors
Author(s): Kristopher A. Kilian; Astrid Magenau; Till Böcking; Katharina Gaus; Michael Gal; J. Justin Gooding
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Paper Abstract

Mesoporous silicon (PSi) photonic crystals have attracted interest as biosensing transducers owing to their high quality optics and sensitivity in optical characteristics to changes in refractive index. We describe progress our group has made derivatizing PSi towards devices for biology and medicine. PSi rugate filters display a high reflectivity resonant line in the reflectance spectrum. As an example for biosensing, immobilization of peptides and biopolymers within the PSi is demonstrated for detecting protease enzymes. Secretion of matrix metalloproteases from live cells was detected as a blue shift in the photonic resonance within hours, demonstrating the promise of this biosensor.

Paper Details

Date Published: 21 August 2009
PDF: 8 pages
Proc. SPIE 7397, Biosensing II, 739703 (21 August 2009);
Show Author Affiliations
Kristopher A. Kilian, Univ. of New South Wales (Australia)
Astrid Magenau, Univ. of New South Wales (Australia)
Till Böcking, Univ. of New South Wales (Australia)
Katharina Gaus, Univ. of New South Wales (Australia)
Michael Gal, Univ. of New South Wales (Australia)
J. Justin Gooding, Univ. of New South Wales (Australia)

Published in SPIE Proceedings Vol. 7397:
Biosensing II
Manijeh Razeghi; Hooman Mohseni, Editor(s)

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