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Proceedings Paper

Nano-β-tricalcium phosphate/collagen materials with improved biostability for bone replacement applications
Author(s): Oana Craciunescu; Christu Tardei; Lucia Moldovan
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Paper Abstract

Three mixtures of collagen (COL) solution and nano-β-tricalcium phosphate (n-β-TCP) powder, with dry weight ratios of 1:1; 1:2.6 and 1:5, respectively were prepared. After freeze-drying, porous three-dimensional (3D) scaffolds were obtained. COL/β-n-TCP scaffolds were chemically crosslinked by treatment with carbodiimide. The crosslinking degree, assessed by quantification of free amine groups, decreased with increasing n-β-TCP quantities. In vitro degradation test showed a better biostability of the chemically cross-linked scaffolds over non-treated ones. All crosslinked scaffolds presented a good cytocompatibility and supported cell proliferation at 48 h and 72 h after cell seeding. These results indicated that EDC cross-linked COL/n-β-TCP scaffolds are potential candidates for bone substitutes with enhanced biostability and good biocompatibility.

Paper Details

Date Published: 7 January 2009
PDF: 4 pages
Proc. SPIE 7297, Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies IV, 72971B (7 January 2009); doi: 10.1117/12.823658
Show Author Affiliations
Oana Craciunescu, National Institute for Biological Sciences (Romania)
Christu Tardei, ICPE SA (Romania)
Lucia Moldovan, National Institute for Biological Sciences (Romania)

Published in SPIE Proceedings Vol. 7297:
Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies IV
Paul Schiopu; Cornel Panait; George Caruntu; Adrian Manea, Editor(s)

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