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Proceedings Paper

Cellular model studies of brain-mediated phototherapy on Alzheimer's disease
Author(s): Ling Zhu; Timon Cheng-Yi Liu; Bina Hu; Xiao-Yun Li; Yong-Qing Wang
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Paper Abstract

Alzheimer's disease (AD) is now the most common neurodegenerative disease. Despite approval of several drugs for AD, the disease continues to rob millions of their memories and their lives. We have studied the cellular models of brain-mediated phototherapy on AD, and the studies will be reviewed in this paper. Genetic studies have shown that dysfunction of amyloid β-protein (Aβ) or tau is sufficient to cause AD. Aβ or Aβ induced redox stress induced neuron apoptosis might be as a cellular model of AD. We found red light at 640±15 nm from light emitting diode array (RLED640) might inhibit Aβ 25-35 induced PC12 cell apoptosis, which is mediated by cyclic adenosine monophosphate, and it might inhibit hydrogen peroxide (H2O2) induced differentiated PC12 cell (dPC12) apoptosis, which is mediated by tyrosine hydroxylase. There is rhythm dysfunction in AD. We found low intensity 810 nm laser irradiation might rehabilitate TNF-alpha induced inhibition of clock gen expression of NIH 3T3 fibroblasts. Our studies provide a foundation for photobiomodulation on brain to rehabilitate AD.

Paper Details

Date Published: 6 March 2009
PDF: 6 pages
Proc. SPIE 7280, Seventh International Conference on Photonics and Imaging in Biology and Medicine, 72801E (6 March 2009); doi: 10.1117/12.823335
Show Author Affiliations
Ling Zhu, South China Normal Univ. (China)
Timon Cheng-Yi Liu, South China Normal Univ. (China)
Bina Hu, South China Normal Univ. (China)
Pingdingshan College of Education (China)
Xiao-Yun Li, South China Normal Univ. (China)
Yong-Qing Wang, South China Normal Univ. (China)
Institute of Psychology (China)

Published in SPIE Proceedings Vol. 7280:
Seventh International Conference on Photonics and Imaging in Biology and Medicine
Qingming Luo; Lihong V. Wang; Valery V. Tuchin, Editor(s)

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