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Proceedings Paper

A singlet oxygen monitor as an in vivo photodynamic therapy dosimeter
Author(s): S. Lee; K. Galbally-Kinney; M. F. Hinds; J. A. O'Hara; B. W. Pogue; A. Liang; T. Hasan; S. J. Davis
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Paper Abstract

In this paper we describe the development and testing of instruments to measure singlet molecular oxygen produced by the photodynamic process. Singlet oxygen is an active species in photodynamic therapy, and we are developing two instruments for PDT researchers with the goal of a real-time dosimeter for singlet oxygen. We discuss both an ultrasensitive point sensor, and an imaging system that provides simultaneous 2D maps of the photosensitizer fluorescence and the singlet oxygen emission. Results of in vitro tests to characterize the sensors and preliminary in vivo results are presented.

Paper Details

Date Published: 13 July 2009
PDF: 9 pages
Proc. SPIE 7380, Photodynamic Therapy: Back to the Future, 738046 (13 July 2009);
Show Author Affiliations
S. Lee, Physical Sciences Inc. (United States)
K. Galbally-Kinney, Physical Sciences Inc. (United States)
M. F. Hinds, Physical Sciences Inc. (United States)
J. A. O'Hara, Dartmouth-Hitchcock Medical Ctr. (United States)
B. W. Pogue, Dartmouth-Hitchcock Medical Ctr. (United States)
A. Liang, Wellman Ctr. for Photomedicine, MGH (United States)
T. Hasan, Wellman Ctr. for Photomedicine, MGH (United States)
S. J. Davis, Physical Sciences Inc. (United States)

Published in SPIE Proceedings Vol. 7380:
Photodynamic Therapy: Back to the Future
David H. Kessel, Editor(s)

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