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Proceedings Paper

Effectiveness in total reduction of Candida albicans promoted by PDT with hypocrellin B:lanthanum
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Paper Abstract

In this work we described the potentiality of the Hypocrellin B (HB) modified with the presence of lanthanum (La3+) ions, in eliminate Candida albicans in suspension. The results showed that the presence of lanthanum ions promotes a red shift of the HB absorption band and an enhancement in singlet oxygen quantum yield in 32%. Also in this work we obtained that the best molar ration between HB and La concentrations was 1:2. No photobleaching was observed in our experimental conditions. Antimicrobial activity was studied exciting C. albicans suspension with a 460 nm LED and a 660 nm laser both with 330 mW/cm2 irradiance. Best irradiation time, PS concentration and ROS production profile were determined showing that using 460 nm LED with 10 μM of PS, only 30 s of irradiation time was sufficient to reduce 100 % C. albicans colonies.

Paper Details

Date Published: 13 July 2009
PDF: 10 pages
Proc. SPIE 7380, Photodynamic Therapy: Back to the Future, 738060 (13 July 2009); doi: 10.1117/12.823013
Show Author Affiliations
Daniel J. Tofolli, Instituto de Pesquisas Energéticas e Nucleares (Brazil)
Renato A. Prates, Instituto de Pesquisas Energéticas e Nucleares (Brazil)
Martha S. Ribeiro, Instituto de Pesquisas Energéticas e Nucleares (Brazil)
Nilson D. Vieira Jr., Instituto de Pesquisas Energéticas e Nucleares (Brazil)
M. C. E. Hashimoto, Instituto de Pesquisas Energéticas e Nucleares (Brazil)
Lilia C. Courrol, Univ. Federal de São Paulo (Brazil)


Published in SPIE Proceedings Vol. 7380:
Photodynamic Therapy: Back to the Future
David H. Kessel, Editor(s)

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