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Proceedings Paper

Effect of hyperthermia on PDT and imaging
Author(s): Avinash Srivatsan; K. V. R. Rao; Yihui Chen; Yanfang Wang; Carrie Batt; Janet Morgan; Arindam Sen; Elizabeth Repasky; Ravindra K. Pandey
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Paper Abstract

Photodynamic Therapy (PDT) is emerging as a successful tool to treat both malignant and benign tumors. It involves the interaction of a photosensitizer which upon activation by the appropriate light dose, leads to a cytotoxic and vasculotoxic photodynamic reaction. Improvements in PDT in areas such as the delivery and selectivity of photosensitizers, light-delivery and overall efficacy have helped to increase its attractiveness as an option for therapy. For optimizing the PDT treatment by a "see and treat approach," we have developed a number of tumor avid photosensitizers (PS) namely HPPH-Cyanine dye conjugates or other compounds (Iodinated photosensitizers) which have the ability for Optical and/or PET imaging as well as being effective photosensitizers for treatment. Hyperthermia refers to various techniques of heat application which may be delivered as a single modality or as part of an adjunct treatment option to the existing cancer therapies. Depending upon the temperature range used, hyperthermia might either directly induce cell kill or enhance the efficacy of other treatment modalities. Hyperthermia increases blood flow within the body, which may allow for higher dose delivery of photosensitizers with subsequent increased therapeutic efficacy of PDT. Hyperthermia could also increase the sensitivity of molecular imaging. The use of multifunctional photosensitizers for imaging and PDT is an emerging area and we have developed a few such agents in our lab. We wish to explore the use of hyperthermia to improve the use of such multifunctional photosensitizers from the point of view of imaging and/or therapy. Hyperthermia can be performed either as a whole-body mode or as localized mode. Our goal is to see which of the two heating modalities offers us better outcome.

Paper Details

Date Published: 13 July 2009
PDF: 10 pages
Proc. SPIE 7380, Photodynamic Therapy: Back to the Future, 73805V (13 July 2009); doi: 10.1117/12.822992
Show Author Affiliations
Avinash Srivatsan, Roswell Park Cancer Institute (United States)
K. V. R. Rao, Roswell Park Cancer Institute (United States)
Yihui Chen, Roswell Park Cancer Institute (United States)
Yanfang Wang, Roswell Park Cancer Institute (United States)
Carrie Batt, Roswell Park Cancer Institute (United States)
Janet Morgan, Roswell Park Cancer Institute (United States)
Arindam Sen, Roswell Park Cancer Institute (United States)
Elizabeth Repasky, Roswell Park Cancer Institute (United States)
Ravindra K. Pandey, Roswell Park Cancer Institute (United States)

Published in SPIE Proceedings Vol. 7380:
Photodynamic Therapy: Back to the Future
David H. Kessel, Editor(s)

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