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Proceedings Paper

Multifunctional ORMOSIL and PAA nanoparticles
Author(s): Anurag Gupta; K. V. R. Rao; Paula Pera; Shouyan Jason Wang; Joseph R. Missert; Tymish Ohulchanskyy; Indrajit Roy; Janet Morgan; Paras N. Prasad; Raoul Kopelman; Ravindra K. Pandey
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Paper Abstract

Various problems arising during molecular imaging of different fluoroprobes and metabolites used in PDT can be circumvented by focusing on multifunctional therapy agents. Thus an effective photo sensitizer coupled with other useful roles to play in PDT treatment make nanoparticles as a good vehicle for different delivery assuming multifunctional roles not only in PDT but also as therapeutic agents for targeted delivery. A new approach is the involving use of 100 nm NPs as photo sensitizers and/or imaging agents. In our Lab., we employ two such NPs and are ORMOSIL (organically Modified Silica) and PAA (Polyacrylamide) which are found to be biologically very safe without disturbing the therapeutic value. The size of the nanoparticles determined by TEM and Dynamic Light Scattering are ~30 nm. These NPs are taken up in conjunction with cyanine dye at near infra red as it has been reported in literature that encapsulated NPs shows very low singlet oxygen production compared with the post-loaded NPs though the reasons are not yet clear. Therefore, we investigated the idea of post-loading or adsorbing vis-a-vis encapsulation.

Paper Details

Date Published: 13 July 2009
PDF: 12 pages
Proc. SPIE 7380, Photodynamic Therapy: Back to the Future, 73805H (13 July 2009); doi: 10.1117/12.822939
Show Author Affiliations
Anurag Gupta, Roswell Park Cancer Institute (United States)
K. V. R. Rao, Roswell Park Cancer Institute (United States)
Paula Pera, Roswell Park Cancer Institute (United States)
Shouyan Jason Wang, Univ. of Michigan (United States)
Joseph R. Missert, Roswell Park Cancer Institute (United States)
Tymish Ohulchanskyy, SUNY at Buffalo (United States)
Indrajit Roy, SUNY at Buffalo (United States)
Janet Morgan, Roswell Park Cancer Institute (United States)
Paras N. Prasad, SUNY at Buffalo (United States)
Raoul Kopelman, Univ. of Michigan (United States)
Ravindra K. Pandey, Roswell Park Cancer Institute (United States)
SUNY at Buffalo (United States)

Published in SPIE Proceedings Vol. 7380:
Photodynamic Therapy: Back to the Future
David H. Kessel, Editor(s)

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