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Proceedings Paper

Surface-enhanced Raman spectroscopy study of the interaction of antitumoral drug Paclitaxel with human serum albumin
Author(s): Tianxiu Yan; Huaimin Gu; Xiaojuan Yuan; Jiwei Wu; Huajiang Wei
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Paper Abstract

SERS spectroscopy was employed to study the interaction of the antitumoral drug paclitaxel with human serum albumin. The normal Raman spectrum of the paclitaxel was shown in this study for the first time. There were some differences existing in the surface-enhanced Raman scattering (SERS) spectrum of paclitaxel and its human serum albumin (HSA), which demonstrated that there was high bioaffinity of paclitaxel to human serum albumin. And it was also found that there existed some differences in the SERS of the paclitaxel/HSA complexes at different pH values, which may indicated some significant information on the binding site, by which paclitaxel binds to human serum albumin. It can provide significant instruction in the synthesis of the drug and in improving the therapeutic efficacy of this drug.

Paper Details

Date Published: 6 March 2009
PDF: 6 pages
Proc. SPIE 7280, Seventh International Conference on Photonics and Imaging in Biology and Medicine, 72800N (6 March 2009); doi: 10.1117/12.821462
Show Author Affiliations
Tianxiu Yan, South China Normal Univ. (China)
Huaimin Gu, South China Normal Univ. (China)
Xiaojuan Yuan, South China Normal Univ. (China)
Jiwei Wu, South China Normal Univ. (China)
Huajiang Wei, South China Normal Univ. (China)

Published in SPIE Proceedings Vol. 7280:
Seventh International Conference on Photonics and Imaging in Biology and Medicine
Qingming Luo; Lihong V. Wang; Valery V. Tuchin, Editor(s)

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