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Proceedings Paper

Application of optical coherence tomography for imaging of scaffold structure and micro-flows characterization
Author(s): B. Veksler; E. Kobzev; M. Bonesi; Igor Meglinski
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Paper Abstract

Tissue engineering, rapidly developing branch of bioscience, is widely adopted for the purposes of the tissue growing using the substrate materials. Three-dimensional porous scaffolds possess a great opportunity for the directional growth of the cells and for the supplying them with nutrients. However, the complex porous structure of the scaffolds creates difficulties for the measurements and control of nutrients flow. We applied optical coherence tomography (OCT) for imaging of the scaffold structure. We also investigated the possibility of using Doppler OCT to monitor the flow velocity distribution within the scaffold. The average scaffold's pore diameter has been estimated using electron microscopy. We show that with Doppler OCT it is possible to monitor complex micro-flow and estimate the shear stress (i.e. enhancing factor of cell growing) acting on the cells within the scaffold and to find the optimal input flow rate, consequently.

Paper Details

Date Published: 30 December 2008
PDF: 5 pages
Proc. SPIE 7139, 1st Canterbury Workshop on Optical Coherence Tomography and Adaptive Optics, 71390C (30 December 2008); doi: 10.1117/12.820993
Show Author Affiliations
B. Veksler, Cranfield Univ. (United Kingdom)
E. Kobzev, Cranfield Univ. (United Kingdom)
M. Bonesi, Cranfield Univ. (United Kingdom)
Igor Meglinski, Cranfield Univ. (United Kingdom)

Published in SPIE Proceedings Vol. 7139:
1st Canterbury Workshop on Optical Coherence Tomography and Adaptive Optics
Adrian Podoleanu, Editor(s)

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