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Proceedings Paper

SmartHEALTH: a microfluidic multisensor platform for POC cancer diagnostics
Author(s): Claudia Gärtner; Holger Becker; Cornelia Carstens; Frithjof von Germar; Klaus Stefan Drese; Alex Fragoso; Rainer Gransee; Andreas Guber; Dirk Herrmann; Nadine Hlawatsch; Richard Klemm; Daniel Latta; Ciara O'Sullivan; Jesus Ruano-Lopez
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Paper Abstract

A universal microfluidic platform as a multisensor device for cancer diagnostics, developed within the framework of the EU project SmartHEALTH [1], will be presented. Based on a standardization concept, a microfluidic platform was realized that contains various functional modules in order to allow in its final setup to run a complete diagnostic assay on a chip starting with sample preparation to a final detection via a sensor array. A twofold concept was pursued for the development and standardization: On the one hand, a standard footprint with defined areas for special functional elements was chosen, on the other hand a toolbox-approach [2] was used whereas in a first instance different functional fluidic modules were realized, evaluated and afterwards integrated into the microfluidic multisensor platform. One main characteristic of the platform is that different kind of sensors can be used with the same fluidic chip. For the read-out and fluidic control of the chip, common fluidic interfaces to the instrument were defined. This microfluidic consumable is a hybrid system consisting of a polymer component with an integrated sensor, reagent storage on chip, integrated valves and metering elements.

Paper Details

Date Published: 24 April 2009
PDF: 8 pages
Proc. SPIE 7313, Smart Biomedical and Physiological Sensor Technology VI, 73130B (24 April 2009); doi: 10.1117/12.820311
Show Author Affiliations
Claudia Gärtner, Microfluidic ChipShop GmbH (Germany)
Holger Becker, Microfluidic ChipShop GmbH (Germany)
Cornelia Carstens, Microfluidic ChipShop GmbH (Germany)
Frithjof von Germar, Institut für Mikrotechnik Mainz GmbH (Germany)
Klaus Stefan Drese, Institut für Mikrotechnik Mainz GmbH (Germany)
Alex Fragoso, Univ. Rovira i Virgili (Spain)
Rainer Gransee, Institut für Mikrotechnik Mainz GmbH (Germany)
Andreas Guber, Research Ctr. Karlsruhe (Germany)
Dirk Herrmann, Research Ctr. Karlsruhe (Germany)
Nadine Hlawatsch, Microfluidic ChipShop GmbH (Germany)
Richard Klemm, Microfluidic ChipShop GmbH (Germany)
Daniel Latta, Institut für Mikrotechnik Mainz GmbH (Germany)
Ciara O'Sullivan, Univ. Rovira i Virgili (Spain)
Jesus Ruano-Lopez, IKERLAN (Spain)

Published in SPIE Proceedings Vol. 7313:
Smart Biomedical and Physiological Sensor Technology VI
Brian M. Cullum; D. Marshall Porterfield, Editor(s)

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