Nanoplasmonic resonance spectroscopy enhances sensitivity and throughput of conventional SPR detection technique while still suffers with modest molecular specificity. Here we demonstrated a new sensing technique --- nano plasmonic resonance energy transfer (PRET) spectroscopy to detect complex biomolecular activities including conformational change, electron transfer and protein interactions with ultrahigh sensitivity and specificity. Compared to FRET sensing technology, PRET has much stronger optical signal to noise ratio and minimal photobleaching problems. Nano PRET spectroscopic molecular imaging technique can be used in multiplexed label-free cancer biomarker detections and environmental sensing applications.

Date Published: 30 April 2009
PDF: 12 pages
Proc. SPIE 7312, Advanced Environmental, Chemical, and Biological Sensing Technologies VI, 731204 (30 April 2009); doi: 10.1117/12.819052

Published in SPIE Proceedings Vol. 7312:
Advanced Environmental, Chemical, and Biological Sensing Technologies VI
Tuan Vo-Dinh; Robert A. Lieberman; Günter Gauglitz, Editor(s)