Share Email Print

Proceedings Paper

Preparation of lisinopril-capped gold nanoparticles for molecular imaging of angiotensin-converting enzyme
Author(s): Yuan Li; Cesar Baeta; Omer Aras; Marie-Christine Daniel
Format Member Price Non-Member Price
PDF $17.00 $21.00

Paper Abstract

Overexpression of angiotensin-converting enzyme (ACE) has been associated with the pathophysiology of cardiac and pulmonary fibrosis. Moreover, the prescription of ACE inhibitors, such as lisinopril, has shown a favorable effect on patient outcome for patients with heart failure or systemic hypertension. Thus targeted imaging of the ACE would be of crucial importance for monitoring tissue ACE activity as well as the treatment efficacy in heart failure. In this respect, lisinopril-coated gold nanoparticles were prepared to provide a new type of probe for targeted molecular imaging of ACE by tuned K-edge computed tomography (CT) imaging. The preparation involved non-modified lisinopril, using its primary amine group as the anchoring function on the gold nanoparticles surface. The stable lisinopril-coated gold nanoparticles obtained were characterized by UV-vis spectroscopy, dynamic light scattering (DLS), transmission electron microscopy (TEM). Their zeta potential was also measured in order to assess the charge density on the modified gold nanoparticles (GNPs).

Paper Details

Date Published: 24 April 2009
PDF: 8 pages
Proc. SPIE 7313, Smart Biomedical and Physiological Sensor Technology VI, 731304 (24 April 2009); doi: 10.1117/12.818226
Show Author Affiliations
Yuan Li, Univ. of Maryland, Baltimore County (United States)
Cesar Baeta, Univ. of Maryland, Baltimore County (United States)
Omer Aras, Univ. of Maryland Hospital and School of Medicine (United States)
Marie-Christine Daniel, Univ. of Maryland, Baltimore County (United States)

Published in SPIE Proceedings Vol. 7313:
Smart Biomedical and Physiological Sensor Technology VI
Brian M. Cullum; D. Marshall Porterfield, Editor(s)

© SPIE. Terms of Use
Back to Top