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Proceedings Paper

Enhanced drug transport through alginate biofilms using magnetic nanoparticles
Author(s): Shayna L. McGill; Carla Cuylear; Natalie L Adolphi; Marek Osinski; Hugh Smyth
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Paper Abstract

The development of microbiological biofilms greatly reduces the efficacy of antibiotic therapies and is a serious problem in chronic infection and for implantable medical devices. We investigated the potential of superparamagnetic nanoparticles to increase transport through in vitro models of alginate biofilms. An in vitro alginate biofilm model was developed to mimic the composition of in vivo samples of P. aeruginosa infections. Transport through this model biofilm was performed using both bulk diffusion methods and single particle tracking techniques in the presence and absence of an external magnetic field. Bulk diffusion of nanoparticles through the biofilm was significantly enhanced in the presence of a magnetic field, both visually and quantitatively. Nanoparticle trajectories also showed transport increases were significantly higher when magnetic fields were applied. We also showed that surface chemistry (cationic, anioni, or neutral) of the nanoparticles significantly influenced transport rates. Finally, nanoparticle size also influenced the transport rates and variability of transport rates through the biofilm. In these first studies using magnetic nanoparticles in bacterial biofilms, we demonstrate that transport enhancement can be achieved and further studies are warranted.

Paper Details

Date Published: 3 March 2009
PDF: 8 pages
Proc. SPIE 7189, Colloidal Quantum Dots for Biomedical Applications IV, 718918 (3 March 2009); doi: 10.1117/12.816830
Show Author Affiliations
Shayna L. McGill, Univ. of New Mexico College of Pharmacy (United States)
Carla Cuylear, Univ. of New Mexico College of Pharmacy (United States)
Natalie L Adolphi, Univ. of New Mexico School of Medicine (United States)
Marek Osinski, Ctr. for High Technology Materials (United States)
Hugh Smyth, Univ. of New Mexico College of Pharmacy (United States)

Published in SPIE Proceedings Vol. 7189:
Colloidal Quantum Dots for Biomedical Applications IV
Marek Osinski; Thomas M. Jovin M.D.; Kenji Yamamoto M.D., Editor(s)

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