
Proceedings Paper
Photodynamic therapy for pancreatic and biliary tract carcinomaFormat | Member Price | Non-Member Price |
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Paper Abstract
Patients with non-resectable pancreatic and biliary tract cancer (cholangiocarcinoma and gallbladder cancer) have a
dismal outlook with conventional palliative therapies, with a median survival of 3-9 months and a 5 year survival of less
than 3%. Surgery is the only curative treatment but is appropriate in less than 20% of cases, and even then is associated
with a 5-year survival of less than 30%. Although most applications of photodynamic therapy (PDT) in gastroenterology
have been on lesions of the luminal gut, there is increasing experimental and clinical evidence for its efficacy in cancers
of the pancreas and biliary tract. Our group has carried out the only clinical study of PDT in pancreatic carcinoma
reported to date, and showed that PDT is feasible for local debulking of pancreatic cancer. PDT has also been used with
palliative intent in patients with unresectable cholangiocarcinoma, with patients treated with stenting plus PDT reporting
improvements in cholestasis, quality of life and survival compared with historical or randomized controls treated with
stenting alone. Further controlled studies are needed to establish the influence of PDT and chemotherapy on the survival
and quality of life of patients with pancreatic and biliary tract carcinoma.
Paper Details
Date Published: 18 February 2009
PDF: 10 pages
Proc. SPIE 7164, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVIII, 71640J (18 February 2009); doi: 10.1117/12.814850
Published in SPIE Proceedings Vol. 7164:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVIII
David H. Kessel, Editor(s)
PDF: 10 pages
Proc. SPIE 7164, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVIII, 71640J (18 February 2009); doi: 10.1117/12.814850
Show Author Affiliations
Stephen P. Pereira, Univ. College London (United Kingdom)
Published in SPIE Proceedings Vol. 7164:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVIII
David H. Kessel, Editor(s)
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