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Proceedings Paper

Direct reconstruction of PET receptor binding parametric images using a simplified reference tissue model
Author(s): Guobao Wang; Jinyi Qi
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Paper Abstract

Molecular imaging using dynamic positron emission tomography (PET) can provide in vivo images of physiologically or biochemically important parameters. Direct reconstruction of parametric images from dynamic PET sinograms is statistically more efficient than the conventional indirect methods, which perform image reconstruction and kinetic modeling in two separate steps. Most existing direct reconstruction methods are derived based on a known blood input function. This paper presents a direct reconstruction algorithm using a simplified reference tissue model, which does not require a blood input function. We have derived a minorization-maximization algorithm to find the penalized maximum likelihood solution. Computer simulations show that the proposed method has better bias-variance tradeoff than the conventional indirect method for estimating parametric images of receptor binding potential using dynamic PET.

Paper Details

Date Published: 13 March 2009
PDF: 8 pages
Proc. SPIE 7258, Medical Imaging 2009: Physics of Medical Imaging, 72580V (13 March 2009); doi: 10.1117/12.813910
Show Author Affiliations
Guobao Wang, Univ. of California, Davis (United States)
Jinyi Qi, Univ. of California, Davis (United States)

Published in SPIE Proceedings Vol. 7258:
Medical Imaging 2009: Physics of Medical Imaging
Ehsan Samei; Jiang Hsieh, Editor(s)

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