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Proceedings Paper

Clinical multiphoton tomography and clinical two-photon microendoscopy
Author(s): Karsten König; Rainer Bückle; Martin Weinigel; Peter Elsner; Martin Kaatz
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Paper Abstract

We report on applications of high-resolution clinical multiphoton tomography based on the femtosecond laser system DermaInspectTM with its flexible mirror arm in Australia, Asia, and Europe. Applications include early detection of melanoma, in situ tracing of pharmacological and cosmetical compounds including ZnO nanoparticles in the epidermis and upper dermis, the determination of the skin aging index SAAID as well as the study of the effects of anti-aging products. In addition, first clinical studies with novel rigid high-NA two-photon 1.6 mm GRIN microendoscopes have been conducted to study the effect of wound healing in chronic wounds (ulcus ulcera) as well as to perform intrabody imaging with subcellular resolution in small animals.

Paper Details

Date Published: 25 February 2009
PDF: 9 pages
Proc. SPIE 7183, Multiphoton Microscopy in the Biomedical Sciences IX, 718319 (25 February 2009); doi: 10.1117/12.813395
Show Author Affiliations
Karsten König, Saarland Univ. (Germany)
JenLab GmbH (Germany)
Rainer Bückle, JenLab GmbH (Germany)
Martin Weinigel, JenLab GmbH (Germany)
Peter Elsner, Friedrich-Schiller-Univ. Jena (Germany)
Martin Kaatz, Friedrich-Schiller-Univ. Jena (Germany)

Published in SPIE Proceedings Vol. 7183:
Multiphoton Microscopy in the Biomedical Sciences IX
Ammasi Periasamy; Peter T. C. So, Editor(s)

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