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Proceedings Paper

Clinical utility of magnetic resonance thermal imaging (MRTI) for realtime guidance of deep hyperthermia
Author(s): P. R. Stauffer; Oana I. Craciunescu; P. F. Maccarini; Cory Wyatt; K. Arunachalam; O. Arabe; V. Stakhursky; B. Soher; J. R. MacFall; Z. Li; William T. Joines; S. Rangarao; K. S. Cheng; S. K. Das; Carlos D. Martins; Cecil Charles; Mark W. Dewhirst; T. Wong; E. Jones M.D.; Z. Vujaskovic M.D.
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Paper Abstract

A critical need has emerged for volumetric thermometry to visualize 3D temperature distributions in real time during deep hyperthermia treatments used as an adjuvant to radiation or chemotherapy for cancer. For the current effort, magnetic resonance thermal imaging (MRTI) is used to measure 2D temperature rise distributions in four cross sections of large extremity soft tissue sarcomas during hyperthermia treatments. Novel hardware and software techniques are described which improve the signal to noise ratio of MR images, minimize motion artifact from circulating coupling fluids, and provide accurate high resolution volumetric thermal dosimetry. For the first 10 extremity sarcoma patients, the mean difference between MRTI region of interest and adjacent interstitial point measurements during the period of steady state temperature was 0.85°C. With 1min temporal resolution of measurements in four image planes, this noninvasive MRTI approach has demonstrated its utility for accurate monitoring and realtime steering of heat into tumors at depth in the body.

Paper Details

Date Published: 25 February 2009
PDF: 12 pages
Proc. SPIE 7181, Energy-based Treatment of Tissue and Assessment V, 71810I (25 February 2009); doi: 10.1117/12.812188
Show Author Affiliations
P. R. Stauffer, Duke Univ. (United States)
Oana I. Craciunescu, Duke Univ. (United States)
P. F. Maccarini, Duke Univ. (United States)
Cory Wyatt, Duke Univ. (United States)
K. Arunachalam, Duke Univ. (United States)
O. Arabe, Duke Univ. (United States)
V. Stakhursky, Duke Univ. (United States)
B. Soher, Duke Univ. (United States)
J. R. MacFall, Duke Univ. (United States)
Z. Li, Duke Univ. (United States)
William T. Joines, Duke Univ. (United States)
S. Rangarao, Duke Univ. (United States)
K. S. Cheng, Duke Univ. (United States)
S. K. Das, Duke Univ. (United States)
Carlos D. Martins, Duke Univ. (United States)
Cecil Charles, Duke Univ. (United States)
Mark W. Dewhirst, Duke Univ. (United States)
T. Wong, Duke Univ. (United States)
E. Jones M.D., Duke Univ. (United States)
Z. Vujaskovic M.D., Duke Univ. (United States)

Published in SPIE Proceedings Vol. 7181:
Energy-based Treatment of Tissue and Assessment V
Thomas P. Ryan, Editor(s)

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