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Proceedings Paper

Revisiting optical clearing with dimethyl sulfoxide (DMSO): in vitro and in vivo studies
Author(s): R. Anthony McClure; Charles Stoianovici; Sanjeev Karma; Bernard Choi
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Paper Abstract

Functional optical characterization of disease progression and response to therapy suffers from loss of spatial resolution and imaging depth due to scattering, impacting the ability of researchers to localize and quantify molecular processes. Here we report on the ability of dimethyl sulfoxide (DMSO) to reduce temporarily the optical scattering of skin. Data collected from in vitro phantom images and in vivo fluorescence images demonstrate the potential of this simple method to mitigate the blurring effects of scattering with topical application, which we expect will improve the accuracy and localization of in vivo molecular imaging studies.

Paper Details

Date Published: 24 February 2009
PDF: 8 pages
Proc. SPIE 7187, Biomedical Applications of Light Scattering III, 718707 (24 February 2009); doi: 10.1117/12.810888
Show Author Affiliations
R. Anthony McClure, Univ. of California, Irvine (United States)
Charles Stoianovici, Univ. of California, Irvine (United States)
Sanjeev Karma, Univ. of California, Irvine (United States)
Bernard Choi, Univ. of California, Irvine (United States)

Published in SPIE Proceedings Vol. 7187:
Biomedical Applications of Light Scattering III
Adam Wax; Vadim Backman, Editor(s)

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