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Proceedings Paper

The role of reactive oxygen species in PDT efficacy
Author(s): Michael Price; Nakaiya Okan-Mensah; Ann Marie Santiago; David Kessel
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Paper Abstract

While the first reactive oxygen species (ROS) formed during photodynamic therapy (PDT) is singlet molecular oxygen (1O2), other ROS are formed downstream including superoxide anion radical (•CO2 -), hydrogen peroxide (H2O2) and hydroxyl radical (•OH). In this study, we examined the role of H2O2 in the phototoxic response to PDT in murine leukemia L388 cells. Inhibition of catalase activity, a major pathway to H2O2 detoxification, led to enhanced apoptosis and cell death. Addition of exogenous catalase offered protection from phototoxicity as did chelation of Fe+2, a co-factor in •OH production from H2O2. These results indicate the H2O2 formed during PDT plays a role in PDT efficacy.

Paper Details

Date Published: 18 February 2009
PDF: 6 pages
Proc. SPIE 7164, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVIII, 716402 (18 February 2009); doi: 10.1117/12.810231
Show Author Affiliations
Michael Price, Wayne State Univ. School of Medicine (United States)
Nakaiya Okan-Mensah, Wayne State Univ. School of Medicine (United States)
Ann Marie Santiago, Wayne State Univ. School of Medicine (United States)
David Kessel, Wayne State Univ. School of Medicine (United States)


Published in SPIE Proceedings Vol. 7164:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVIII
David H. Kessel, Editor(s)

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