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Proceedings Paper

Dynamic photophysical processes in laser irradiated human cortical skull bone
Author(s): Andreas Mandelis; Chi-Hang Kwan; Anna Matvienko
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Paper Abstract

Modulated luminescence (LUM) technique was applied to analyze photophysical processes in the cortical layer of human skull bones. The theoretical interpretation of the results was based on the optical excitation and decay rate equations of the fluorophore and on the molecular interaction parameter with the photon field density in the matrix of the bone. Using comparisons of the theory with the frequency response of dental LUM it was concluded that the optically active molecular species (fluorophore) in the bones is hydroxyapatite. An effective relaxation lifetime of skull cortical bone was derived theoretically and was found to depend on the intrinsic fluorophore decay lifetime, on the photon field density, and on the thickness of the bone. The experimentally measured dependencies were in excellent agreement with the theoretical model. The theory was able to yield measurements of the optical scattering coefficient, optical absorption coefficient, and mean coupling coefficient. These results show that the quantitative LUM can be used as a sensitive method to measure optical properties of the active fluorophore in cortical skull bones and the optical-field-induced molecular interaction parameter. When calibrated vs. laser intensity, the modulated luminescence can also be used to measure human skull thickness. These traits can be applied to monitor the bone mineral density (BMD) and, ultimately can be used as potential markers of bone health or disease, such as osteoporosis or bone cancer.

Paper Details

Date Published: 18 February 2009
PDF: 12 pages
Proc. SPIE 7166, Optics in Bone Biology and Diagnostics, 71660A (18 February 2009); doi: 10.1117/12.810084
Show Author Affiliations
Andreas Mandelis, Univ. of Toronto (Canada)
Chi-Hang Kwan, Univ. of Toronto (Canada)
Anna Matvienko, Univ. of Toronto (Canada)

Published in SPIE Proceedings Vol. 7166:
Optics in Bone Biology and Diagnostics
Andreas Mandelis, Editor(s)

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