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Proceedings Paper

Multimodal scanning laser ophthalmoscopy for image guided treatment of age-related macular degeneration
Author(s): Daniel X. Hammer; R. Daniel Ferguson; Ankit H. Patel; Nicusor V. Iftimia; Mircea Mujat; Deeba Husain
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Paper Abstract

Subretinal neovascular membranes (SRNM) are a deleterious complication of laser eye injury and retinal diseases such as age-related macular degeneration (AMD), choroiditis, and myopic retinopathy. Photodynamic therapy (PDT) and anti-vascular endothelial growth factor (VEGF) drugs are approved treatment methods. PDT acts by selective dye accumulation, activation by laser light, and disruption and clotting of the new leaky vessels. However, PDT surgery is currently not image-guided, nor does it proceed in an efficient or automated manner. This may contribute to the high rate of re-treatment. We have developed a multimodal scanning laser ophthalmoscope (SLO) for automated diagnosis and image-guided treatment of SRNMs associated with AMD. The system combines line scanning laser ophthalmoscopy (LSLO), fluorescein angiography (FA), indocyanine green angiography (ICGA), PDT laser delivery, and retinal tracking in a compact, efficient platform. This paper describes the system hardware and software design, performance characterization, and automated patient imaging and treatment session procedures and algorithms. Also, we present initial imaging and tracking measurements on normal subjects and automated lesion demarcation and sizing analysis of previously acquired angiograms. Future pre-clinical testing includes line scanning angiography and PDT treatment of AMD subjects. The automated acquisition procedure, enhanced and expedited data post-processing, and innovative image visualization and interpretation tools provided by the multimodal retinal imager may eventually aid in the diagnosis, treatment, and prognosis of AMD and other retinal diseases.

Paper Details

Date Published: 18 February 2009
PDF: 13 pages
Proc. SPIE 7163, Ophthalmic Technologies XIX, 71631C (18 February 2009); doi: 10.1117/12.810050
Show Author Affiliations
Daniel X. Hammer, Physical Sciences Inc. (United States)
R. Daniel Ferguson, Physical Sciences Inc. (United States)
Ankit H. Patel, Physical Sciences Inc. (United States)
Nicusor V. Iftimia, Physical Sciences Inc. (United States)
Mircea Mujat, Physical Sciences Inc. (United States)
Deeba Husain, Boston Univ. School of Medicine (United States)

Published in SPIE Proceedings Vol. 7163:
Ophthalmic Technologies XIX
Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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