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Proceedings Paper

Iron oxide nanoparticle hyperthermia and chemotherapy cancer treatment
Author(s): A. A. Petryk; A. J. Giustini; P. Ryan; R. R. Strawbridge; P. J. Hoopes
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Paper Abstract

The benefit of combining hyperthermia and chemotherapy to treat cancer is well established. However, combined therapy has not yet achieved standard of care status. The reasons are numerous and varied, however the lack of significantly greater tumor cell sensitivity to heat (as compared to normal cells) and the inability to deliver heat to the tumor in a precise manner have been major factors. Iron oxide nanoparticle (IONP) hyperthermia, alone and combined with other modalities, offers a new direction in hyperthermia cancer therapy via improved tumor targeting and an improved therapeutic ratio. Our preliminary studies have demonstrated tumor cell cytotoxicity (in vitro and in vivo) with IONP heat and cisplatinum (CDDP) doses lower than those necessary when using conventional heating techniques or cisplatinum alone. Ongoing studies suggest such treatment could be further improved through the use of targeted nanoparticles.

Paper Details

Date Published: 23 February 2009
PDF: 7 pages
Proc. SPIE 7181, Energy-based Treatment of Tissue and Assessment V, 71810N (23 February 2009); doi: 10.1117/12.810024
Show Author Affiliations
A. A. Petryk, Dartmouth College (United States)
A. J. Giustini, Dartmouth College (United States)
Dartmouth Medical School (United States)
P. Ryan, Massachusetts College of Pharmacy and Health Sciences (United States)
R. R. Strawbridge, Dartmouth Medical School (United States)
P. J. Hoopes, Dartmouth College (United States)
Dartmouth Medical School (United States)

Published in SPIE Proceedings Vol. 7181:
Energy-based Treatment of Tissue and Assessment V
Thomas P. Ryan, Editor(s)

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