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Proceedings Paper

Second harmonic generation imaging of the collagen in myocardium for atrial fibrillation diagnosis
Author(s): Ming-Rung Tsai; Yu-We Chiou; Chi-Kuang Sun
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Paper Abstract

Myocardial fibrosis, a common sequela of cardiac hypertrophy, has been shown to be associated with arrhythmias in experimental models. Some research has indicated that myocardial fibrosis plays an important role in predisposing patients to atrial fibrillation. Second harmonic generation (SHG) is an optically nonlinear coherent process to image the collagen network. In this presentation, we observe the SHG images of the collagen matrix in atrial myocardium and we analyzed of collagen fibers arrangement by using Fourier-transform analysis. Moreover, comparing the SHG images of the collagen fibers in atrial myocardium between normal sinus rhythm (NSR) and atrial fibrillation (AF), our result indicated that it is possible to realize the relation between myocardial fibrosis and AF.

Paper Details

Date Published: 23 February 2009
PDF: 10 pages
Proc. SPIE 7161, Photonic Therapeutics and Diagnostics V, 71612O (23 February 2009); doi: 10.1117/12.809950
Show Author Affiliations
Ming-Rung Tsai, National Taiwan Univ. (Taiwan)
Yu-We Chiou, Far Eastern Memorial Hospital (Taiwan)
Chi-Kuang Sun, National Taiwan Univ. (Taiwan)
Research Ctr. for Applied Sciences (Taiwan)

Published in SPIE Proceedings Vol. 7161:
Photonic Therapeutics and Diagnostics V
Henry Hirschberg M.D.; Brian Jet-Fei Wong M.D.; Kenton W. Gregory M.D.; Reza S. Malek; Nikiforos Kollias; Bernard Choi; Guillermo J. Tearney; Justus F. R. Ilgner; Steen J. Madsen; Laura Marcu; Haishan Zeng, Editor(s)

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