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Proceedings Paper

Velocity-resolved single-pass volumetric retinal flow imaging spectral domain optical coherence tomography
Author(s): Yuankai K. Tao; Kristen M. Kennedy; Joseph A. Izatt
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Paper Abstract

Advances in Doppler spectral domain optical coherence tomography (SDOCT) have demonstrated several image acquisition schemes that enable real-time, high-resolution, volumetric display of blood flow maps. Current generation Doppler SDOCT systems use phase differences between sequential A-scans acquired at a single spatial position to calculate the velocity of moving scatterers. Recently, several methods for optical angiography have been developed which resolve moving scatterers by imposing a spatial frequency modulation across a lateral scan dimension. The carrier frequency is generated by adding a reference phase delay using a moving reference arm or an off-pivot scanning beam. The resulting data is spatial frequency windowed such that all moving scatterers (flow) modulating the carrier frequency can be separated from non-moving scatterers (structure). However, spatial frequency modulation requires precise synchronization of the reference arm delay with B-scan acquisition and multiple B-scans are required to image bidirectional flow into and out-of the A-scan axis. Here we demonstrate single-pass volumetric bidirectional blood flow imaging (SPFI) SDOCT using a modified Hilbert transform without the use of spatial frequency modulation. By windowing low-spatial frequency scatterers across a B-scan, bidirectionally moving scatterers centered at Doppler frequencies outside of the frequency window are resolved. Additionally, 3D velocimetry maps can be constructed by setting the spatial frequency window to a corresponding velocity range and shifting it across all spatial frequencies to image scatterers moving within a particular velocity range. We show that SPFI SDOCT allows for 3D imaging of in vivo human retinal microvasculature down to 20μm, thus providing information about vessel morphology and dynamics.

Paper Details

Date Published: 19 February 2009
PDF: 4 pages
Proc. SPIE 7168, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIII, 716809 (19 February 2009); doi: 10.1117/12.809921
Show Author Affiliations
Yuankai K. Tao, Duke Univ. (United States)
Kristen M. Kennedy, Duke Univ. (United States)
Joseph A. Izatt, Duke Univ. (United States)

Published in SPIE Proceedings Vol. 7168:
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIII
James G. Fujimoto; Joseph A. Izatt; Valery V. Tuchin, Editor(s)

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