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Enhancement of transdermal delivery of glycerol by micro-needling method combined with sonophoresis
Author(s): Jinhee Yoon; Donghee Park; Taeyoon Son; Jongbum Seo; Byungjo Jung
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Paper Abstract

The light does not penetrate deeply into the skin tissue because of tissue turbidity. Light penetration depth in skin tissue can be increased by using optical clearing agents such as glycerol, glucose and dimethyl sulfoxide(DMSO). The stratum corneum prevents most optical skin clearing agent from diffusing into the tissue. Previous studies demonstrated the optical tissue clearing effect using optical clearing agents and presented several physical methods to improve transdermal delivery of optical clearing agents. In previous study, we introduced a micro-needling method to enhance optical clearing efficacy against skin barrier and suggested quantitative analysis method to evaluate the optical tissue clearing efficacy. In this study, we present a new physical micro-needling method combined with sonophoresis to further enhance the optical tissue clearing efficacy. The optical tissue clearing effect was quantitatively evaluated with a modulation transfer function target placed under ex-vivo porcine skin samples. To improve transdermal delivery of glycerol, 70% glycerol solution as optimal concentration was topically applied. In conclusion, the samples treated with micro-needling method and sonophoresis resulted in noticeable optical tissue clearing effect.

Paper Details

Date Published: 19 February 2009
PDF: 6 pages
Proc. SPIE 7161, Photonic Therapeutics and Diagnostics V, 716109 (19 February 2009);
Show Author Affiliations
Jinhee Yoon, Yonsei Univ. (Korea, Republic of)
Donghee Park, Yonsei Univ. (Korea, Republic of)
Taeyoon Son, Yonsei Univ. (Korea, Republic of)
Jongbum Seo, Yonsei Univ. (Korea, Republic of)
Byungjo Jung, Yonsei Univ. (Korea, Republic of)

Published in SPIE Proceedings Vol. 7161:
Photonic Therapeutics and Diagnostics V
Henry Hirschberg M.D.; Brian Jet-Fei Wong M.D.; Kenton W. Gregory M.D.; Reza S. Malek; Nikiforos Kollias; Bernard Choi; Guillermo J. Tearney; Justus F. R. Ilgner; Steen J. Madsen; Laura Marcu; Haishan Zeng, Editor(s)

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