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Proceedings Paper

Three-dimensional photoacoustic tomography of small animal brain with a curved array transducer
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Paper Abstract

We present the application of an optimized curved array photoacoustic tomographic imaging system, which can provide rapid, high-resolution photoacoustic imaging of small animal brains. The system can produce a B-mode, 90-degree field-of-view image at sub-200 μm resolution at a frame rate of ~1 frame/second when a 10-Hz pulse repetition rate laser is employed. By rotating samples, a complete 360-degree scan can be achieved within 15 seconds. In previous work, two-dimensional ex vivo mouse brain cortex imaging has been reported. In the current work, we report three-dimensional small animal brain imaging obtained with the curved array system. The results are presented as a series of two-dimensional cross-sectional images. Besides structural imaging, the blood oxygen saturation of the animal brain cortex is also measured in vivo. In addition, the system can measure the time-resolved relative changes in blood oxygen saturation level in the small animal brain cortex. Finally, ultrasonic gel coupling, instead of the previously adopted water coupling, is conveniently used in near-real-time 2D imaging.

Paper Details

Date Published: 12 February 2009
PDF: 9 pages
Proc. SPIE 7177, Photons Plus Ultrasound: Imaging and Sensing 2009, 71770K (12 February 2009); doi: 10.1117/12.809590
Show Author Affiliations
Xinmai Yang, Washington Univ. in St. Louis (United States)
Lihong V. Wang, Washington Univ. in St. Louis (United States)
Anastasios Maurudis, Univ. of Connecticut (United States)
John Gamelin, Univ. of Connecticut (United States)
Andres Aguirre, Univ. of Connecticut (United States)
Quing Zhu, Univ. of Connecticut (United States)

Published in SPIE Proceedings Vol. 7177:
Photons Plus Ultrasound: Imaging and Sensing 2009
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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