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Proceedings Paper

Image-guided optical spectroscopy in diagnosis of osteoarthritis by combining spectral and spatial a priori information
Author(s): Zhen Yuan; Qizhi Zhang; Huizhu Jiang; Eric S. Sobel; Huabei Jiang
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Paper Abstract

A multi-modality imaging approach and instrument that integrate optical imaging system and near-infrared spectroscopy into an x-ray tomosynthesis setup have been employed to perform a clinical study of image-guided spectroscopy on osteoarthritis (OA) in the finger joints. The multiwavelength spectroscopy of the joints using x-ray-guided spatial constraints provides 3D images of oxygen saturation and water content with high resolution and improved quantitative capability. Based on the recovered quantitative results from 18 healthy volunteers and 22 patients, we observed that oxygen saturation and water content were significant discriminators for differentiation of healthy joints from diseased ones. The recovered images appear to show that the OA joints have high water values and decreased oxygen saturation.

Paper Details

Date Published: 12 February 2009
PDF: 12 pages
Proc. SPIE 7174, Optical Tomography and Spectroscopy of Tissue VIII, 71740K (12 February 2009); doi: 10.1117/12.809556
Show Author Affiliations
Zhen Yuan, Univ. of Florida (United States)
Qizhi Zhang, Univ. of Florida (United States)
Huizhu Jiang, Univ. of Florida (United States)
Eric S. Sobel, Univ. of Florida (United States)
Huabei Jiang, Univ. of Florida (United States)

Published in SPIE Proceedings Vol. 7174:
Optical Tomography and Spectroscopy of Tissue VIII
Bruce J. Tromberg; Arjun G. Yodh; Mamoru Tamura; Eva M. Sevick-Muraca; Robert R. Alfano, Editor(s)

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