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Proceedings Paper

Tomographic x-ray guided three-dimensional diffuse optical imaging of osteoarthritis in the finger joints: a clinical study
Author(s): Zhen Yuan; Huizhu Jiang; Qizhi Zhang; Eric S. Sobel; Huabei Jiang
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Paper Abstract

To investigate the typical optical findings that can be used to characterize osteoarthritis, the distal interphalangeal finger joints from 40 subjects including 22 patients and 18 healthy controllers were examined clinically and scanned by a novel hybrid imaging system. The hybrid imaging platform integrated a C-arm based x-ray tomosynthetic system with a multi-channel optic-fiber based diffuse optical imaging system. Optical images were recovered qualitatively and quantitatively based on a regularization-based reconstruction algorithm that can incorporate the fine structural maps obtained from x-ray as a priori spatial information into diffuse optical tomography reconstruction procedures. Our findings suggest statistically significant differences between healthy and osteoarthritis finger joints. X-ray guided diffuse optical imaging may not only detect radiologic features supporting the development of an inflammatory disorder but may also help discriminate specific optical features that differ between osteoarthritic and healthy joints. These quantitative optical features are also potentially important for a better understanding of inflammatory arthritis in humans.

Paper Details

Date Published: 18 February 2009
PDF: 11 pages
Proc. SPIE 7166, Optics in Bone Biology and Diagnostics, 71660G (18 February 2009); doi: 10.1117/12.809466
Show Author Affiliations
Zhen Yuan, Univ. of Florida (United States)
Huizhu Jiang, Univ. of Florida (United States)
Qizhi Zhang, Univ. of Florida (United States)
Eric S. Sobel, Univ. of Florida (United States)
Huabei Jiang, Univ. of Florida (United States)

Published in SPIE Proceedings Vol. 7166:
Optics in Bone Biology and Diagnostics
Andreas Mandelis, Editor(s)

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