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Proceedings Paper

Automated Raman spectral preprocessing of bone and other musculoskeletal tissues
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Paper Abstract

Raman spectroscopy of bone is complicated by fluorescence background and spectral contributions from other tissues. Full utilization of Raman spectroscopy in bone studies requires rapid and accurate calibration and preprocessing methods. We have taken a step-wise approach to optimize and automate calibrations, preprocessing and background correction. Improvements to manual spike removal, white light correction, software image rotation and slit image curvature correction are described. Our approach is concisely described with a minimum of mathematical detail.

Paper Details

Date Published: 18 February 2009
PDF: 10 pages
Proc. SPIE 7166, Optics in Bone Biology and Diagnostics, 716605 (18 February 2009); doi: 10.1117/12.809436
Show Author Affiliations
Francis W. L. Esmonde-White, Univ. of Michigan (United States)
Matthew V. Schulmerich, Univ. of Michigan (United States)
Karen A. Esmonde-White, Univ. of Michigan (United States)
Michael D. Morris, Univ. of Michigan (United States)

Published in SPIE Proceedings Vol. 7166:
Optics in Bone Biology and Diagnostics
Andreas Mandelis, Editor(s)

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