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Proceedings Paper

Limits to non-fluorescent voltage sensitivity using surface and particle plasmons
Author(s): Mark C. Pitter; John Paul; Jing Zhang; Michael G. Somekh
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Paper Abstract

Voltage sensitive fluorescent dyes have long been used to measure physiological voltages in live cell cultures. However dyes suffer from poor contrast and limited recording duration due to photobleaching. A photostable voltage sensitive cellular label, such as a noble metal nanoparticle, would potentially allow for indefinite recording from neural and other live cell cultures. Noble metals possess an inherent voltage sensitivity: their optical properties depend on their density of free electrons, which can be modulated in an aqueous environment by charging or discharging the double layer capacitance with an applied voltage. This manuscript contains a simple analysis of the expected voltage sensitivity using gold nanospheres and nanoshells in both darkfield and photothermal detection modalities and concludes that high bandwidth voltage measurement is fundamentally achievable.

Paper Details

Date Published: 23 February 2009
PDF: 12 pages
Proc. SPIE 7180, Photons and Neurons, 718006 (23 February 2009); doi: 10.1117/12.809060
Show Author Affiliations
Mark C. Pitter, The Univ. of Nottingham (United Kingdom)
John Paul, The Univ. of Nottingham (United Kingdom)
Jing Zhang, The Univ. of Nottingham (United Kingdom)
Michael G. Somekh, The Univ. of Nottingham (United Kingdom)

Published in SPIE Proceedings Vol. 7180:
Photons and Neurons
Anita Mahadevan-Jansen; E. Duco Jansen, Editor(s)

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