
Proceedings Paper
Optimization of physiological parameter for macroscopic modeling of reacted singlet oxygen concentration in an in-vivo modelFormat | Member Price | Non-Member Price |
---|---|---|
$17.00 | $21.00 |
Paper Abstract
Singlet oxygen (1O2) is generally believed to be the major cytotoxic agent during photodynamic therapy (PDT), and the
reaction between 1O2 and tumor cells define the treatment efficacy. From a complete set of the macroscopic kinetic
equations which describe the photochemical processes of PDT, we can express the reacted 1O2 concentration, [1O2]rx, in
a form related to time integration of the product of 1O2 quantum yield and the PDT dose rate. The production of [1O2]rx
involves physiological and photophysical parameters which need to be determined explicitly for the photosensitizer of
interest. Once these parameters are determined, we expect the computed [1O2]rx to be an explicit dosimetric indicator
for clinical PDT. Incorporating the diffusion equation governing the light transport in turbid medium, the spatially and
temporally-resolved [1O2]rx described by the macroscopic kinetic equations can be numerically calculated. A sudden
drop of the calculated [1O2]rx along with the distance following the decrease of light fluence rate is observed. This
suggests that a possible correlation between [1O2]rx and necrosis boundary may occur in the tumor subject to PDT
irradiation. In this study, we have theoretically examined the sensitivity of the physiological parameter from two clinical
related conditions: (1) collimated light source on semi-infinite turbid medium and (2) linear light source in turbid
medium. In order to accurately determine the parameter in a clinical relevant environment, the results of the computed
[1O2]rx are expected to be used to fit the experimentally-measured necrosis data obtained from an in vivo animal model.
Paper Details
Date Published: 18 February 2009
PDF: 12 pages
Proc. SPIE 7164, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVIII, 71640O (18 February 2009); doi: 10.1117/12.809024
Published in SPIE Proceedings Vol. 7164:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVIII
David H. Kessel, Editor(s)
PDF: 12 pages
Proc. SPIE 7164, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVIII, 71640O (18 February 2009); doi: 10.1117/12.809024
Show Author Affiliations
Ken Kang-Hsin Wang, Univ. of Pennsylvania (United States)
Theresa M. Busch, Univ. of Pennsylvania (United States)
Theresa M. Busch, Univ. of Pennsylvania (United States)
Jarod C. Finlay, Univ. of Pennsylvania (United States)
Timothy C. Zhu, Univ. of Pennsylvania (United States)
Timothy C. Zhu, Univ. of Pennsylvania (United States)
Published in SPIE Proceedings Vol. 7164:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVIII
David H. Kessel, Editor(s)
© SPIE. Terms of Use
